Christina Applegate's friends fearing the worst as 'hellish' details of star's hospitalization are revealed: report

Christina Applegate’s friends are reportedly worried for the “Married … With Children” star following her recent hospitalization, fearing the worst as more “hellish” details are revealed amid her multiple sclerosis diagnosis.

“With every setback, if we are being realistic, everyone has it in the back of their minds that they might not have a tomorrow with her,” a source told Daily Mail in a report published on Friday.

“Christina is a fighter, but her battle with MS has been treacherous. She has better days and really bad days; she doesn’t have great days. She’s always dealing with something. It sucks.”

Christina Applegate’s friends are reportedly fearing the worst for the actress (pictured above on stage with a mic at the Light Up The Blues 7 Concert) amid her battle with MS following her recent hospitalization. Getty Images
“Everyone has it in the back of their minds that they might not have a tomorrow with her,” a source said of Applegate’s diagnosis. AFP via Getty Images

The insider added: “But when she does look at things positively it makes her feel better in the moment because she has so many friends that are there for her, even to listen to her, cry with her and anything in between.”

The news comes shortly after it was reported that Applegate, 54, had been hospitalized in Los Angeles last month.

It remains unclear if the reason behind her extended hospital visit has to do with her autoimmune disease at this time.

When reached for comment, a rep for the actress told Page Six: “I have no comment on whether she is in the hospital or what her medical treatments are. She’s had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast.”

“But when she does look at things positively it makes her feel better in the moment because she has so many friends that are there for her,” the insider added of Applegate (seen above at the 75th Emmy Awards ceremony). AFP via Getty Images
The update comes shortly after it was revealed Applegate had been hospitalized in late March. Getty Images

Applegate — who revealed her MS diagnosis in August 2021 — has been open about her health journey, giving updates via various interviews and her “MesSy” podcast, which she co-hosts with Jamie-Lynn Sigler.

Most recently, she admitted in February that she’s been confined to her bed due to ongoing pain. She made the confession while telling People that she still tries to take her daughter, Sadie — who she shares with her husband Martyn LeNoble — to school in the mornings.

“I want to take her; it’s my favorite thing to do. It’s the only time we have together by ourselves,” she told the outlet.

“I tell myself, ‘Just get her there safely and get home so you can get back into bed.’ And that’s what I do.”

The “Married … With Children” actress, pictured above at the 28th annual Critics Choice Awards, revealed in February that she had been confined to her bed due to ongoing pain as a result of her MS. Getty Images for Critics Choice Association
Applegate, pictured here at the 29th annual Screen Actors Guild Awards, last shared she was hospitalized in August 2025 for a kidney infection. FilmMagic

Applegate last revealed she was hospitalized on an August 2025 episode of her podcast, sharing that she was “screaming” from being in “so much pain.”

On the episode, she recalled feeling like “my appendix is bursting” after she felt an excruciating pain on her side.

At the time, doctors informed her that she had a kidney infection that has since spread to her other kidney.

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